Keep your hands on the keyboard whenever possible. You can do a lot without having to touch your mouse.
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Show and hide Floaters while in any app with the global keyboard shortcut: ⌘`You can customize this and other global shortcuts in the Preferences window.
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Move and resize windows using just the keyboard
Use ⌘M to move or ⌘R to resize the current floater without using the mouse.
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Global keyboard shortcuts for other actions
By default you can create a new note from any app using ⌘⌥` but you can also customize and add more global keyboard shortcuts in the Settings window.
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Center a floater on the screen with ⌘⌥^0
Or move it to an edge of the screen with ⌘⌥^ and the arrow ↑→↓← keys